COMPARISON OF PNEUMOCOCCAL ABSORBENT PREPARATIONS USED IN HUMAN ANTI-PNEUMOCOCCAL POLYSACCHARIDE (PNPS) ANTIBODY (AB) ELISAS. 1100
نویسندگان
چکیده
منابع مشابه
Pneumococcal Capsular Polysaccharide Vaccine
Streptococcus pneumoniae (pneumococcus [Pnc]) is a common bacterial agent found in mild mucosal as well as severe systemic infections. Local infections, such as acute otitis media, are rather common; every child has at least one during the first 2 years of life (1), and Pnc is the causative agent in approximately half of the bacterial culturepositive cases (2). Pneumonia is another disease ofte...
متن کاملRegulation of the Antibody Response to Type Iii Pneumococcal Polysaccharide
The effect of treatment with antilymphocyte serum (ALS) on the magnitude of the plaque-forming cell (PFC) response to Type III pneumococcal polysaccharide (SSS-III) was assessed in athymic nude mice and thymus-bearing littermate controls. Without ALS treatment, the PFC response was slightly higher in nude than in control mice. Treatment with ALS had no effect on the response of nude mice; howev...
متن کاملThe Anamnestic Antibody Response to Type Iii Specific Pneumococcal Polysaccharide
Rabbits immunized with killed type III pneumococci respond to anamnestic challenge by type specific polysaccharide (S III) with the synthesis of anti-S III antibody if a long interval is allowed to elapse between primary and secondary immunization. A study of the anti-S III antibody produced early and late in the immune response revealed no change in molecular class, banding pattern of dissocia...
متن کاملEstimating the protective concentration of anti-pneumococcal capsular polysaccharide antibodies.
Estimates of minimum protective antibody concentrations for vaccine preventable diseases are of critical importance in assessing whether new vaccines will be as effective as those for which clinical efficacy was shown directly. We describe a method for correlating pneumococcal anticapsular antibody responses of infants immunized with pneumococcal conjugate (PnC) vaccine (Prevenar) with clinical...
متن کاملPurification and characterisation of anti-pneumococcal capsular polysaccharide IgG immunoglobulins.
OBJECTIVES The production of reference materials for quantifying pneumococcal antibody concentrations relies upon large scale vaccination. An alternative simple, reproducible protocol has been developed for the affinity purification of 23 serotype anti-pneumococcal capsular polysaccharide (PCP) IgG immunoglobulins. DESIGN & METHODS The purification protocol utilised IgG fractionation, capsula...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199604001-01122